Abstract
Background: Hand-Foot Syndrome (HFS) is a dermatological toxicity induced by capecitabine (CAP)/fluorouracil (5FU). HFS is related to damage of palmar/plantar epidermal/dermal cells by 5FU, and inflammation-mediated by cyclooxygenase-2 pathways. We hypothesize applying OQL036 a topical gel prodrug metabolizing to thymidine (TdR) and naproxen (NAP) may alleviate HFS toxicity associated with CAP/5FU.
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