Abstract
2135 Rapid 3D vessel wall imaging at 3 T: optimization and evaluation of diffusion preparation
Highlights
Multi-contrast MRI is widely used to image the vessel wall and characterize the composition of atherosclerotic plaques
Standard protocols use 2D multi-slice fast spin echo (FSE) with either double inversion recovery (DIR) [1] or flow saturation bands preparation for blood suppression. 2D methods lack contiguous coverage and suffer from partial voluming affecting plaque quantitation. 3D methods cannot be robustly combined with DIR preparation due to lingering signal from stagnant flow
We demonstrate an 84-second acquisition of 3D bilateral carotid vessel-wall data with 0.5 × 0.5 × 2.5 mm 3 resolution over a 16 × 6.4 × 2 cm 3 FOV, with vessel wall-lumen CNR > 20. 3D acquisitions are combined with diffusion sensitizing gradients" (DSG) preparation for robust blood suppression relative to DIR
Summary
Multi-contrast MRI is widely used to image the vessel wall and characterize the composition of atherosclerotic plaques. Standard protocols use 2D multi-slice fast spin echo (FSE) with either double inversion recovery (DIR) [1] or flow saturation bands preparation for blood suppression. 2D methods lack contiguous coverage and suffer from partial voluming affecting plaque quantitation. An alternative preparation dubbed "diffusion sensitizing gradients" (DSG) causes significant dephasing of flowing spins [2], and has been applied in the carotids with 3D-SSFP imaging [3] which has a restricted set of contrast variations and 2D-FSE imaging [4]. We optimize and evaluate the performance of DSG in conjunction with 3D inner volume imaging (IVI) FSE [5,6] at 3 Tesla
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