Abstract
Patients affected by chronic venous insufficiency (CVI) and Lipodermatosclerosis present characteristic brown colouring of the lower legs due to iron overload, all together predisposing conditions of leg ulcer formation. Therefore, in this project, we aim to investigate the pathological effect of iron overload on the cross-talk of resident immune and tissue cells in the skin. At first, we collected skin samples of CVI patients and confirmed via immunohistochemistry (IHC) a massive accumulation of iron in the dermis.
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