Abstract
Triple-negative breast cancer (TNBC) represents nearly 20% of all breast cancers and is considered to be more aggressive and to have poorer prognosis due to lack of effective treatments. KDM4 is a family of histone demethylases shown to drive cancer by regulating transcription, cell cycle, and DNA replication/repair. Overexpression of KDM4 leading to mistakes in post-translational histone modification is associated with many. cancers, including TNBC.
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