Abstract
Microchimerism during and following pregnancy in species with hemochorial placentation is common. That is, very small numbers of maternal cells are found in the fetus and persist in the offspring, and very small numbers of fetal cells occur and can persist in the mother. The importance of these cells, which are detectable for decades, remains an enigma clinically. Mouse models support the human clinical findings that microchimeric cell populations differentiate and that pregnancy-engrafted cells are associated with autoimmune lesions, sites of cancer, and tissue repair. Expansion of well-designed experiments of pregnancy-induced microchimerism would aid in understanding the importance of these grafts in clinical practice.
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