Abstract
Methods Retrospective cross-sectional study of 40 DMD subjects evaluated from 2004–2006. Each patient underwent standard pulmonary function testing and CMR for clinical indications (mean = 9 months between studies). Collected data included FVC% predicted (FVC%, a marker of ventilatory capacity) and FEV1%; Ejection fraction (LVEF, RVEF), end-diastolic volume (LVEDV, RVEDV), and enddiastolic mass (LVEDM, RVEDM). Spearman rank correlations were performed between pulmonary and cardiac parameters.
Highlights
Duchenne Muscular Dystrophy (DMD), a progressive functional myopathy, is characterized by death from respiratory and/or cardiac failure in early adulthood
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008 Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdf
We hypothesized that due to cardiopulmonary interaction, abnormal pulmonary function in DMD is associated with structural and functional cardiac changes measured by cardiac MRI (CMR)
Summary
2080 Relationship of structural and functional cardiac abnormalities to respiratory status in Duchenne Muscular Dystrophy. Mary McBride*1, Larry Markham, Linda Cripe, Maninder Kalra, Raouf Amin, Janaka Wansapura and William Gottliebson. Address: 1St Louis Childrens Hospital, St. Louis, MO, USA, 2Vanderbilt Childrens Hospital, Nashville, TN, USA and 3Cincinnati Childrens Hospital Medical Center, Cincinnati, OH, USA. Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A349 doi:10.1186/1532-429X-10-S1-A349. Abstracts of the 11th Annual SCMR Scientific Sessions - 2008 Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdf
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