Abstract
2073 Novel quantitative measures of pulmonary arterial hypertension using MRI – a study in patients with early-stage systemic sclerosis
Highlights
Systemic Sclerosis (SSc) is a progressive systemic disease which can involve the pulmonary arteries and patients suffering from it can develop pulmonary arterial hypertension (PAH)
Stroke volume (SV) and pulmonary blood volume variation (PBVV)/SV were 75 ± 4 ml and 45 ± 2% in patients, and 103 ± 6 ml and 43 ± 3% in healthy volunteers, (p = 0.002 for SV, and p = 0.912 for PBVV/SV)
PBVV correlated to SV (n = 20, R2 = 0.65, p < 0.001)
Summary
Systemic Sclerosis (SSc) is a progressive systemic disease which can involve the pulmonary arteries and patients suffering from it can develop pulmonary arterial hypertension (PAH). We lack quantitative and noninvasive methods to adequately assess PAH. To pass from the pulmonary trunk to the left atrium. The pulmonary volume including lung tissue and the functional residual capacity was measured in all patients using planimetry in axial MRI images covering the entire lung field. The pulmonary blood density (PBD) was defined as the PBV divided by the pulmonary volume. To evaluate the feasibility of using novel magnetic resonance imaging (MRI) methods to identify physiological involvement of the pulmonary circulation in early-stage SSc patients
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