2016 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section.

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Announcements2016 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal SectionPublished Online:15 Apr 2016https://doi.org/10.1152/ajprenal.00105.2016This is the final version - click for previous versionMoreSectionsPDF (158 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat The American Physiological Society (APS) Renal Section has selected David H. Ellison, M.D. as the recipient of the 2016 Carl Gottschalk Distinguished Lectureship. Dr. Ellison is Professor of Medicine and Physiology and Pharmacology, Director of the Oregon Clinical and Translational Research Institute, and Associate Vice President for Clinical and Translational Research at Oregon Health and Science University. Dr. David H. EllisonDownload figureDownload PowerPoint Dr. Ellison graduated from Stanford University with distinction and Departmental Honors in Biology. After receiving his Medical Degree with Alpha Omega Alpha honors from Rush Medical College (Chicago, IL), he trained in Internal Medicine at the University of Oregon Health Sciences Center (Portland, OR) and Nephrology at Yale University. Following a Nephrology Fellowship and postdoctoral training in renal physiology with Dr. Fred Wright, Dr. Ellison joined the faculty at Yale. He then moved to the University of Colorado (Denver, CO), where he was Chief of the Renal Section at the Denver Veterans Affairs Medical Center. Prior to taking his new position, he was Head of the Division of Nephrology and Hypertension at Oregon Health and Science University for the last 13 years.Dr. Ellison's research centers on the molecular target of thiazide diuretics, drugs recommended as first-line antihypertensive agents. A model physician-scientist, all of his work beautifully combines basic and clinical approaches. His early studies showed that the thiazide-sensitive Na-Cl transporter (NCC) is the dominant salt transport pathway along the distal convoluted tubule (DCT) and helped define the physiological and clinical importance of the nephron segment. This work was later translated to provide insights into the mechanisms of loop-diuretic resistance. Dr. Ellison has been a leader in defining how mutations in the NCC cause Gitelman syndrome, a hypokalemic salt-wasting disease in humans and how mutations in the WNK kinase cascade activate the NCC and cause familial hyperkalemic hypertension. His group demonstrated that the immunosuppressive drug tacrolimus causes hyperkalemia and hypertension by activating the NCC. Recently, his studies revealed how the NCC is regulated by dietary potassium, providing new insights to explain the deleterious effects of dietary potassium deficiency on blood pressure. This work also promises to rewrite the textbooks on the mechanisms of altered renal sodium handling in primary aldosteronism and Addison disease.Dr. Ellison has served on many important committees for the American Physiological Society, American Society of Nephrology, and American Heart Association. He was Chair of the Council on the Kidney in Cardiovascular Disease, American Heart Association. He is presently an Associate Editor for the Journal of the American Society of Nephrology. He has also served on numerous national peer review groups. Currently, he is Chair of the Kidney Molecular Biology and Development Study Section for the National Institutes of Health.Dr. Ellison continues to make important contributions to explain the effects of diet on blood pressure, the mechanisms of salt transport by the kidney, the genetic basis of human blood pressure variation, and on diuretic treatment of edema. The Renal Section is honored to have him present the 2016 Carl Gottschalk Distinguished Lecture.This article has no references to display. Download PDF Previous Back to Top Next FiguresReferencesRelatedInformation More from this issue > Volume 310Issue 8April 2016Pages F802-F802 Copyright & PermissionsCopyright © 2016 the American Physiological Societyhttps://doi.org/10.1152/ajprenal.00105.2016PubMed26911847History Published online 15 April 2016 Published in print 15 April 2016 Metrics