Abstract

Announcements2014 Young Investigator Award of the American Physiological Society Renal SectionPublished Online:15 Apr 2014https://doi.org/10.1152/ajprenal.00142.2014This is the final version - click for previous versionMoreSectionsPDF (250 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat fredrik palm, ph.d. is the recipient of the Renal Section Young Investigator Award for 2014. Dr. Palm is an exceptional scientist/educator who represents the best of young investigators in the American Physiological Society (APS).Dr. Fredrik PalmDownload figureDownload PowerPointDr. Palm has always been interested in how the kidney works and how dysfunction can contribute to diseases, such as diabetes and hypertension. He earned his Ph.D. in the laboratories of Drs. Peter Hansell and Per Liss in 2004, having published 16 papers up to that point. Many of these were focused on renal oxygen metabolism and renal hypoxia that occurs in diabetes. He was the first investigator to observe this phenomenon, and much of his subsequent work has searched for the cause and significance of renal diabetic hypoxia. He has published 60 papers (over 20 in APS journals), which is an exceptional level of productivity for this stage of his career.In addition to his discovery of diabetic renal hypoxia, he has targeted mitochondrial function as a potential contributor to this disorder. He has shown that mitochondrial dysfunction can lead to formation of reactive oxygen species, which can impact cellular oxygen consumption. He has localized the key gene/protein in this possible sequence as uncoupling protein-2 (UCP2) and showed that knockdown of UCP2 decreased oxidative stress in the diabetic rat kidney (Friederich-Persson et al., PLoS One, 2012). His more recent work has now confirmed that this pathway may be a major source of superoxide in the normal and diseased kidney.Dr. Palm has been a pioneer in the use of noninvasive imaging as a diagnostic tool for disease and as a renal function marker (Eckerbom et al., Adv Exp Med Biol, 2013; Laustsen et al., Kidney Int, 2013). He is currently leading a multi-institutional program to use these methods in prediabetic and chronic kidney disease patients. This project is a prime example of the translational aspect of his basic physiological approach. His other interests range from control of renal blood flow by a series of locally generated vasoactive agents, such as adenosine, arginine, nitric oxide, prostaglandins, and c-peptide, to understanding renal oxygen usage. He has mastered multiple techniques, such as renal micropuncture, radiological imaging, mitochondrial isolation, living animal cardiovascular and renal function, and cell and molecular biology. In this day of specialization, he is unique as to his wide range of skills and experience. These skills help him advance his program in multiple disciplines.After completion of his Ph.D., Dr. Palm sought further training as a postdoctoral fellow with Dr. C. S. Wilcox at Georgetown University, where he learned techniques to measure single-nephron function and oxygen metabolism and advanced his imaging experiences. During this time, he spent 6 weeks in the EPR laboratory of Dr. Harold Swartz at Dartmouth College to learn this valuable technique to quantify ROS in biological fluids. Near the end of his postdoctoral training, he was awarded a K-99 grant from the National Institutes of Health on diabetic renal nephropathy. His first faculty position was in the Division of Nephrology at Georgetown University in 2008, where he continues to have an adjunct appointment. However, in 2011 he was recruited to Linkoping University in Sweden as a Professor in Experimental Renal Medicine to start a research program in this unit. He also maintains a laboratory at Uppsala University. His rapid successes are partially due to his outstanding publications, but also to his stellar ability to obtain funding for his research program. He has been awarded 17 grants, after his Ph.D. training; over $5 million during this period. This includes a K99-R00 award from 2008 to 2012. The other highlighted awards are a Swedish Research Council grant, 2009–2015 (equivalent to an NIH R-01), Swedish Heart and Lung Foundation, 2010–2014 [equivalent to American Heart Association (AHA) Grant-in-Aid], and two separate Institutional grants.He has won numerous awards for his research, including the prestigious Melvin H. Knisely Award from the International Society of Oxygen Transport to Tissue, the Benzelious Award from the Swedish Royal Society of Sciences and the “Paper of the Year” for the American Journal of Physiology-Renal Physiology in 2008 (“Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: Implications for renomedullary oxygen availability”). He is also a Fellow of the American Heart Association. He has been invited to lecture by multiple organizations and has guest chaired 10 sessions. He is sought out as an expert in diabetic nephropathy and renal oxygen usage.He is now a recognized educator as well. He has directed two completed Ph.D. students, codirected three others, and currently has two Ph.D. students in his laboratory. He is a regular lecturer in physiology courses in both graduate and medical school curricula.Dr. Palm has an exceptional record in research and education and will be an influential and productive renal physiologist over the course of his career. He is an outstanding choice for the Young Investigator Award from the Renal Section of the APS.This article has no references to display. Download PDF Previous Back to Top FiguresReferencesRelatedInformation More from this issue > Volume 306Issue 8April 2014Pages F928-F929 Copyright & PermissionsCopyright © 2014 the American Physiological Societyhttps://doi.org/10.1152/ajprenal.00142.2014History Published online 15 April 2014 Published in print 15 April 2014 Metrics

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