Abstract

Immune checkpoint inhibitors (ICIs) are now widely used in monotherapy or in combination with chemotherapy in advanced non-small cell lung cancer (NSCLC), and in combination with chemotherapy in advanced small-cell lung cancer (SCLC). However, few data are currently available concerning the acquired resistance mechanisms to ICIs in lung cancer. There is therefore a need for systematic prospective collection of tumor samples for histological and molecular analyses at the time of progression.

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