Abstract
Cytokinesis is the final process of cell division, in which a cell body is mechanically separated into two daughter cells. The changes in cell shape are regulated by not only the actomyosin contractile ring but also global cell-surface mechanics whose properties are predominantly provided from cytoskeleton. The spatial and temporal dynamics of cell-surface mechanics and its underlying regulatory mechanisms, however, are not well understood. It is technically difficult to directly measure cell-surface mechanical parameters with high spatio-temporal resolution. Here, we are trying to construct an indirect method for predicting the spatio-temporal dynamics of the mechanical parameters in which experimentally observed cell shapes and mathematical models are employed. By using this method, we are predicting spatio-temporal change in bending modulus, an index of cell-surface stiffness. We will also discuss the application of this method for illuminating the mechanisms conferring morphological phenotypes in various cvtokinesis mutant cells.
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