Abstract
Locoregional drug delivery has demonstrated the potential to increase therapeutic efficacy while reducing off-target toxicity. Nanogel-based drug delivery has shown great promise in addressing the challenges and overcoming limitations associated with systemic drug administration. Nanogels can encapsulate drugs or drug-loaded carriers to provide sustained, localized drug delivery via various routes of administration, such as intranasal, intraocular, intracranial, endoscopic, bone transplantation, nerve root injection, and dermal applications. For instance, ReGel is a thermoresponsive nanogel platform comprised of poly(D,L-lactide-co-glycolide) (PLGA) and polyethylene glycol (PEG) with the basic structure of PLGA-block-PEG-block-PLGA. ReGel makes a thermosensitive transition from a sol into a nanogel at 15%–23% w/w at 37°C. ReGel was able to incorporate and deliver a poorly water-soluble anticancer drug, paclitaxel, locally to treat esophageal cancer using an endoscopic ultrasound-guided injection. This chapter presents an updated summary of recent advances of nanogels in locoregional drug delivery.
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