Abstract
Hydrogels are highly cross-linked polymers that are able to swell with water heavily. They are three-dimensional structures formed mainly from polymers. Hydrogels are characterized as materials with low mechanical parameters and stability. Thereby, they should be cross-linked to improve physicochemical properties. Dual-cross-linking is a novel method to apply two cross-linking factors (physical or chemical). Depending on the type of polymers used to fabricate hydrogels, various cross-linking factors may be proposed. The additional property of hydrogels is their antibacterial activity against both Gram-positive and Gram-negative bacteria. For this purpose, active compounds can be added during the preparation of hydrogels, or hydrogel may be antibacterial in itself.
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