Abstract
This chapter discusses active immunization against luteinizing hormone–releasing hormone (LH–RH) in the female. LH–RH is a decapeptide with a molecular weight of 1181 and is poorly immunogenic. Its immunogenicity can be enhanced by adsorption on to large inert particles such as aluminum oxide, polyvinylpyrollidone or charcoal, but consistency of response and antibody titers improve if LH–RH is bound covalently to a protein carrier. Serum albumins have proved to be the most commonly used proteins especially bovine and human serum albumins. Soon after the isolation and elucidation of structure of porcine LH–RH, synthetic LH–RH became available and was shown subsequently to elicit LH and FSH release in many animal species. The chapter also discusses the effects of active immunization against synthetic LH–RH on the reproductive endocrinology and physiology of the female, and the potential use of the technique as an alternative to ovariectomy.
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