Abstract
Metabolic engineering is a process that modifies the existing metabolic pathways of microorganisms and creates novel biosynthetic routes for the production of biofuels, biomaterials, and environmental applications. Lactic acid bacteria (LAB) are Generally Recognized as Safe (GRAS) microorganisms used as a cell factory worldwide. Gene expression in LAB can be precisely regulated, making it possible to create therapeutics to detect and control specific diseases and deliver drug molecules. In this chapter, the recent development of synthetic biology for the metabolic engineering of LAB is outlined. This chapter also discusses the applications of engineered metabolic LAB in food, fermentation, and pharmaceutical industries.
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