Abstract
Azetidines are an important class of azaheterocycles with extraordinary pharmacological properties, which makes them an interesting synthetic topic. There are several important nonantibiotic applications of 2-azetidinones in areas ranging from enzyme inhibition to gene activation. These pharmacological properties afford the motivation to discover novel procedures for the formation of substances based on the β-lactam core. In comparison to their importance, a relatively low number of reviews, albeit very wide and complete, on their preparation have appeared. The aim of this chapter is to give a review of the reactions of imines and alkenes utilized to synthesize the azetidines.
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