Abstract
About 40% of all B-cell lymphomas are characterized by the presence of recurrent reciprocal chromosomal translocations. The term ‘double-hit' lymphoma is mostly used for mature B cell lymphomas with a chromosomal breakpoint affecting the MYC locus along with another recurrent chromosomal breakpoint. These lymphomas are aggressive and usually show high proliferation rate. Mantle cell lymphoma is a mature B-cell lymphoma characterized by t(11;14) resulting in cyclin D1 over expression. Although rare, a MYC and cyclin D1 double-hit phenomenon can occur in mantle cell lymphoma and is associated with an adverse clinical course and blastoid morphology. We report a case of a 58 years old female with a left maxillary mass histologically showing features of blastoid mantle cell lymphoma. Fluorescence in situ hybridization (FISH) was positive for CCND1 and MYC gene rearrangements. Recognising ‘double-hit' lymphomas, through use of appropriate investigations is important for optimal management of patients with these highly aggressive tumours.
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