Abstract
Characteristics of human primary mantle cell lymphoma engraftment in NSG mice.
Highlights
In recent years, improved understanding of lymphoma biology has led to the development of a number of small molecule inhibitors
Murine models of Mantle cell lymphoma (MCL) cell lines are relatively easy to establish in SCID or NOD/SCID/IL2Rc null (NSG) mice (Wang et al, 2007, 2008a; Weston et al, 2010) but have their limitations
Until a couple of years ago, the only primary mouse model of human MCL described in the literature was established by injection of primary MCL cells into subcutaneous human bone grafts implanted in SCID mice (SCID-Hu model) (Wang et al, 2008b)
Summary
Mantle cell lymphoma (MCL) is a clinically heterogeneous, but often aggressive lymphoma characterized by the IGH: CCND1 translocation and cyclin D1 (CCND1) over-expression. At 20 weeks, MCL cells were found in the bone marrow and spleen of mice injected with 2 out of the 7 cryopreserved primary samples. Both samples that engrafted had blastoid morphology and one was obtained from a patient with relapsed disease. Engraftment was seen in mouse spleen and bone marrow on sacrifice at 20 weeks (Fig 2G). In addition to the two cryopreserved samples, evidence of engraftment was seen in the spleen of NSG mice injected with the fresh primary sample (non-blastoid). Representative images showing secondary engraftment of MCL in peripheral blood (12 weeks), bone marrow (20 weeks) and spleen (20 weeks) of NSG mice
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