Abstract

AbstractThe stereoselective synthesis of some 3’‐deoxy‐3’‐C‐methyl pyrimidine nucleosides is reported. The studied modifications concern the inversion of the configuration in 2’‐position as well as the introduction of fluoro and azido substituents. The corresponding arabinonucleoside and 2’‐substituted ribonucleoside analogs of uracil and cytosine have been obtained and fully characterized. Attempts to introduce fluoro and azido substituents with inversion at C‐2’ are also presented.

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