Abstract
A series of NH-acidic 2-anilino-3,5-dinitro-thiophenes (II), 2-anilino-3,4-dinitro-5-halo-thiophenes (VI), and some 3,5-dinitro-thienole-derivatives (IX, X) were synthesized. Compounds II and VI are potent uncouplers of oxidative phosphorylation in rat liver mitochondria. The most active comcounds yielded a 50% uncoupling at a concentration of 10-7 ᴍ. With some of the 2-anilino-3,5-dinitro-5-halo-thiophenes (BDCT or DDCT), added to respiring liver mitochondria, a transitory uncoupling of energy-linked reactions could be observed which is comparable to the phosphorylating cycles produced by ADP. The mechanism of this effect is discussed
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
