Abstract
Purpose: Recent in vitro studies demonstrated a contribution of the sympathetic neurotransmitter norepinephrine (NE) to cellular processes involved in osteoarthritis (OA) pathogenesis. These effects were mediated by different adrenoceptor (AR) subtypes that are expressed in all joint tissues. Most in vitro data suggest that especially the β2-AR plays an important role during OA progression. However, at present, no study exists that investigated the role of the β2-AR in the knee joint in vivo. Therefore, we examined the contribution of the β2-AR to OA progression using β2-AR-deficient (Adrb2-/-) mice.
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