Abstract
Purpose: Recent studies demonstrated a contribution of the sympathetic nervous system and its major neurotransmitter norepinephrine (NE) to osteoarthritis (OA) pathogenesis. The effects of NE mediated by adrenoceptors (ARs) are predominantly catabolic in cartilage and subchondral bone, while mainly anti-inflammatory in the synovial tissue. Several AR subtypes are expressed in different joint tissues but the current literature suggests that the β2-AR plays a crucial role during OA pathogenesis in different joint tissues.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
