Abstract
The mol-ecule of the title compound, C25H18ClF2N5S, comprises almost co-planar fluoro-phenyl, methyl-thia-zolyl, pyrazolyl and chloro-phenyl rings with the second fluoro-phenyl ring almost perpendicular to this plane. One fluoro-phenyl group is disordered over two components of occupancy ratio 0.767 (10):0.233 (10) related by a 24.2 (8)° twist. In the crystal, two mol-ecules related by inversion symmetry are linked by a pair of C-H⋯F contacts in an R(8)2 2 geometry.
Highlights
The molecule of the title compound, C25H18ClF2N5S, comprises almost coplanar fluorophenyl, methylthiazolyl, pyrazolyl and chlorophenyl rings with the second fluorophenyl ring almost perpendicular to this plane
One fluorophenyl group is disordered over two components of occupancy ratio 0.767 (10):0.233 (10) related by a 24.2 (8) twist
Two molecules related by inversion symmetry are linked by a pair of C—HÁ Á ÁF contacts in an R(8)22 geometry
Summary
Various pyrazolinyl thiazoles have pharmacological and biological applications (AbdelWahab et al, 2017; Abd-Rabou et al, 2018; Saeed et al, 2017). Heterocycles containing both pyrazole and thiazole moieties have been used as versatile intermediates in organic synthesis of biologically active compounds (Secrieru et al, 2019; Shaabani et al, 2019; Sharma et al, 2020). We have published the X-ray crystal structures for related heterocycles (El-Hiti, Abdel-Wahab, Alqahtani et al, 2019; El-Hiti, AbdelWahab, Yousif et al, 2019; El-Hiti et al, 2018). Fluorophenyl group E is disordered over two components with an occupancy ratio of 0.767 (10):0.233 (10) and related by a twist of 24.2 (8)
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