Abstract
The title compound, C23H17ClFN5OS, comprises fluorophenyl (A), furanyl (B), pyrazolyl (C), methylthiazoyl (D) and chlorophenyl (E) rings. The B–C–D–E linked ring system is close to planar with the dihedral angles B/C, C/D and D/E being 7.6 (1), 3.4 (1) and 8.4 (1)°, respectively. The fluorophenyl group is almost perpendicular to the pyrazoyl ring, as indicated by an A/C twist angle of 79.4 (1)°. In the crystal, inversion dimers linked by pairs of C—H...S contacts are observed.
Highlights
Structure description Thiazoles are of importance in medicinal chemistry as they have various biological activities (Kashyap et al, 2012) and occur in natural products (Chhabria et al, 2016)
Pyrazoles have a broad spectrum of biological activities (Faria et al, 2017)
As part of our studies in these areas, we describe the structure of the title compound
Summary
The title compound was synthesized by the condensation of 5(4-fluorophenyl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazole-1carbothioamide with N0-(4-chlorophenyl)-2-oxopropanehydrazonoyl chloride in ethanol containing catalytic amount of triethylamine as previously reported (Abdel-Wahab et al, 2013). The product was recrystallized from dimethylformamide solution to give colourless crystals (74%), m.p. 227–228C. Crystal data Chemical formula Mr Crystal system, space group Temperature (K) a, b, c (A ). C23H17ClFN5OS 465.92 Monoclinic, P21/c 298 5.2879 (3), 26.3742 (10), 15.7872 (7) 98.293 (4) 2178.72 (18) 4 Mo K 0.31 0.49 Â 0.16 Â 0.15
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