(1R,5R)-1-(1′-Dimethylaminoethyl)-2-isopropylidene-5-methylcyclohexanol as a Chiral Ligand in the Enantioselective Addition of Diethylzinc to Aldehydes

Abstract

An efficient chiral ligand, (1R,5R)-1-(1′-dimethylaminoethyl)-2-isopropylidene-5-methylcyclohexanol, has been developed for the enantioselective addition of diethylzinc to some prochiral aldehydes to afford S-alcohols. The overall conversion rate was 80-98% with excellent enantiomeric excess (79-98%).