199. The long-term effects of genomic selection: allele frequency changes and fixation of loci

Y.C.J Wientjes,J Van Den Heuvel,B.J Zwaan,Z.G Vitezica,M.P.L Calus,P Bijma

doi:10.3920/978-90-8686-940-4_199

Y.C.J Wientjes, J Van Den Heuvel + Show 4 more

https://doi.org/10.3920/978-90-8686-940-4_199

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Allele frequencies change due to drift and selection. We investigated those changes for different selection methods. We simulated a livestock population with 50 generations of selection for an additive trait controlled by 2,000 segregating loci at the start of selection. Our results show that the average absolute change in allele frequency with genomic selection was slightly higher than with pedigree selection, and considerably higher than with mass selection. Genomic and pedigree selection both resulted in fixation of roughly three times more loci than mass selection, and roughly five times more loci became fixed for the unfavourable allele. While this was mainly a result of increased genetic drift, genomic selection also lost additional favourable alleles due to hitchhiking. This suggests that genomic selection can limit long-term genetic gain.

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