1963P A pan-cancer study of GNAQ/GNA11 mutations in Chinese cancer patients

Abstract

Mutations in GNAQ and GNA11 are early events that promote cell proliferation, and these mutations are sensitive to MAPK kinase, PKC, and AKT inhibitors. Uveal melanoma is characterized by GNAQ/GNA11 mutations, leading to the use of PKC inhibitors as a rational treatment strategy and encouraging clinical activity has been noted recently. The application of PKC inhibitors in other cancers requires a comprehensive understanding of the prevalence and types of GNAQ/GNA11 mutations. Herein, we systematically analyzed our large-scale data to explore the frequency and mutation spectrum of GNAQ/GNA11 in Chinese cancer patients.