Abstract
Background: Angiopoietin-1 (Ang1) is a critical angiogenic factor for vascular maturation and enhances vascular endothelial growth factor (VEGF)-induced angiogenesis in a complementary manner. Previously, we reported that adenoviral vector mediated Ang1 gene therapy clearly promoted myocardial angiogenesis and reduced infarct size in a rat acute myocardial infarction (AMI) model. However, the alternative gene delivery method must explore for clinical application of myocardial Ang1 gene therapy, because of toxicity and inflammatory nature of adenoviral vector. Naked plasmid injection is the safest and convenient method for cardiovascular gene therapy and we have reported that naked CA (CMV enhancer/Chicken β-actin promoter)-promoter can bring remarkable myocardial transgene expression following naked CA-plasmid injection. Therefore, we attempted naked Ang1 plasmid gene therapy for rat AMI model and evaluated myocardial angiogenesis and effects for the remodeling following AMI.
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