Abstract
were observed between PH-S and PH-P. According to response to propranolol prophylaxis status, and ADRB2 polymorphisms (SNP) a significant higher ADRB2 activity was observed in non-responder PH patients. This activity was more pronounced when any of the ADRB2 SNP was present in both, responder and non-responder patients (Fig. 1). Conclusions: Non-responder PH patients to propranolol prophylaxis show a most reactive ADRB2 to adrenergic stimulus compared with responders, in both groups, native or polymorphic patients.
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