18F-FDG PET-CT imaging in the detection of recurrent and metastasis ovarian cancer

Abstract

Objective To investigate the value of 18F-FDG PET-CT in the detection and diagnosis of recurrent and metastasis ovarian cancer.Methods Retrospective analysis of whole body PET-CT imaging data of 65 patients after operation for ovarian cancer.All the case were followed-up for 3-57 months.The diagnosis was confirmed by surgical pathological examination,imaging studies and clinical follow-up.Results Of the 65 patients,55 cases developed tumor recurrence and metastasis,and 10 patients didn't show tumor recurrence and transfer.Of the 180 positive lesions displayed on 18F-FDG PET-CT images,165 lesions were finally diagnosed as recurrence and metastasis,the remaining 15 lesions were identified as lymph node reactive hyperplasia.With 18F-FDG PET-CT,the accurate diagnosis were given in 60 patients (positive in 51 cases and negative in 9 cases),1 given false positive diagnosis,and 4 cases of false negative diagnosis.As a result,the sensitivity,specificity,accuracy,positive-predictive value and negative-predictive value for detecting the ovarian lesions by 18F-FDG PET-CT were 92.7％ (51/55),90.0％ (9/10),93.8％ (61/65),98.1％ (51/52),69.2 ％ (9/13) respectively.Carbohydrate antigen 125 (CA 125) levels had a positive relationships with the results of 18F-FDG PET-CT.The level of CA125 was increased in 47 cases,and positive images were found in 45 cases,the positive rate was 95.7％.Conclusion 18F-FDG PET-CT has a high sensitivity and accuracy in the detection of recurrent and metastasis ovarian cancer.It is recommend to perform 18F-FDG PET-CT,in particular when elevated CA 125 is detected. Key words: Ovarian neoplasms; Neoplasm recurrence, local; Neoplasm metastasis; Fluorodeoxyglucose F18; Positron-emission tomography; Tomography, X-ray computed