Value of 18F-FDG PET-CT in diagnoss of prostate cancer recurrence and metastasis

Abstract

Objective To investigate the value of 18F-FDG PET-CT on patients with suspected prostate cancer recurrence and metastasis. Methods Retrospective analysis 23 patients with prostate cancer who were suspected to have tumor recurrence and metastasis during follow-up, underwent 18F-FDG PET-CT examination. 18F-FDG PET-CT results were compared with those of conventional images, as referred to histopathology or clinical follow-up. Results In total, 19 patients with recurrence and metastasis were confumed by histopathology or clinical follow-up. Twenty patients were found to have positive lesion by 18F-FDG PET-CT, including the pelic abscess (1case), prostate cancer local recurrence (5cases), lymph node metastases(8cases), multiple systemic lymph node metastasis(lcase)and bone metastases(5cases). The sensitivity of 18F-FDG PET-CT was 100% (19/19) in diagnosis carcinoma recurrence and metastasis, and the specificity and accuracy were 75% (3/4) and 95%(22/23). The levels of prostate specific antigen in 12 patients gradually increased after endocrine theraphy, and PET-CT could dipit this accurately. Compared with conventional images such as B mode ultrasonic, CT, bone imaging, 18F-FDG PET-CT could find more focus. Conclusion 18F-FDG PET-CT imaging is valuable in diagnosing recurrent and metastatic prostate cancer. Key words: Prostate neoplasms; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose Fl8; Prostate-specific antigen