Abstract
6-[18F]fluoro-3,4-dihydroxyphenylalanine ([18F]F-DOPA) is a diagnostic positron emission tomography agent, widely used in imaging the loss of dopaminergic neurons in Parkinson’s disease and, recently, to detect, stage and restage neuroendocrine tumors and to search for recurrence of viable glioma tissue.In this paper, we establish a protocol of thermal aging (i.e., heating timescales of the order of 24h and temperatures higher than 120°C) against the swelling and morphological surface degradation (inspected by microscope imaging) of poly(dimethylsiloxane) (PDMS) by dichloromethane (DCM) and hydriodic acid (HI), that are chemicals involved in the microfluidic synthesis of [18F]F-DOPA. Swelling tests on PDMS channels heated at 150°C (for 24 and 48h) and 180°C (for 24h) confirm a percentage change of the channel dimension as low as 2–8% after loading with DCM. Also, X-ray photoelectron spectroscopy analysis is presented to illustrate changes of surface chemistry following treatments with DCM, HI and an aqueous solution containing 19F-fluoride as one of the products (impurities) in the [18F]F-DOPA synthesis. Rinsing with distilled water was demonstrate to allow removal of any chemical contamination from the PDMS surface treated with HI and a [18F]-fluoride-based solution, which is critical to synthesize high-purity (≥98%) [18F]F-DOPA to be clinically used.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.