Abstract
Stress exposure is a major risk factor for mood disorders, such as major depressive disorder and post-traumatic stress disorder. However, some individuals can successfully adapt to stress and this ability is known as stress resilience. We previously reported that a single injection of ketamine prior to stress protects against the development of depressive-like behavior and attenuates learned fear in mice. However, the cellular and molecular pathways underlying ketamine-induced stress resilience are still largely unknown.
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