Abstract

Background: Immunohistochemical staining for the p53 tumor suppressor protein is commonly used as an effective tool in characterizing malignant epithelial lesions. Inflamed seborrheic keratoses (SK) with reactive atypia present a diagnostic challenge as these benign neoplasms may have overlapping histologic features with well differentiated squamous carcinomas. This study evaluated the utility of p53 immunohistochemistry in distinguishing benign and malignant proliferative skin lesions.

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