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PDF Availablehttps://doi.org/10.1016/j.annonc.2021.08.270
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Cite Journal: Annals of Oncology |  Publication Date: Sep 1, 2021 |
 License type: publisher-specific-oa |
Affiliation: National Medical Research Center of Cardiology
CHEK2-associated neoplasms account for a significant proportion of hereditary breast cancer (BC). The contribution of loss of heterozygosity (LOH) phenomenon to the pathogenesis of CHEK2-dependent tumors remains poorly understood, and almost all available data concern only one mutation type - CHEK2 1100delC.
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