Abstract
Patients with cardiovascular diseases have greatly benefited from the development of various vascular procedures and devices such as tissue engineered vascular graft (TEVG). TEVGs have successfully been used clinically in the low-pressure venous circulation system of pediatric patients. However, small-diameter arterial TEVGs have not yet been successfully translated into clinical applications. Electrospun nanofiber TEVGs have strong potential for use in the arterial circulation system due to their excellent mechanical properties, bioactivity, and biocompatibility. However, despite their promising potential, the precise mechanisms of vascular remodeling and neotissue formation in electrospun TEVGs have yet to be elucidated. Thus, a multidisciplinary approach involving the positive translational participation of biologists, engineers, and clinicians is needed to fully understand and incorporate this technology to the clinic.
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