Abstract
179 Human umbilical mesenchymal stem cells-seeded bladder acellular matrix grafts for reconstruction of bladder defects in a canine model
Highlights
The repair of bladder defects caused by trauma or tumors is often problematic and poses a serious challenge for urological surgeons [1]
Conclusions/Significance: Our preliminary results demonstrate that Umbilical mesenchymal stem cells (UMSCs)-seeded Bladder acellular matrix graft (BAMG) are superior to unseeded BAMGs to promote the regeneration of bladder defects
Our findings indicated that human umbilical mesenchymal stem cells (HUMSCs) may be a potential cell source for bladder tissue engineering
Summary
The repair of bladder defects caused by trauma or tumors is often problematic and poses a serious challenge for urological surgeons [1]. The development of tissue engineering techniques will bring new opportunities for bladder reconstruction [2]. These techniques involve seeding biomaterial scaffolds with appropriate cells in the laboratory and implanting them in vivo to repair or regenerate damaged tissue [3]. Certain studies have reported that transplantation of biomaterial seeded with autologous urothelial and smooth muscle cells could allow for the regeneration of a functional bladder in several animal models [4,5,6]. The goal of this study was to explore the feasibility of utilizing human umbilical mesenchymal stem cells (HUMSCs)-seeded Bladder acellular matrix graft (BAMG) for bladder reconstruction in a canine model
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