Abstract
ent between group 1 and group 2 (19.7 vs 24.5 months). Statistically significant predictors of death included presence of sarcomatoid features(HR 2.4: 95%CI 1.5–3.8), pathologic T and N stage (HR 2.0: CI 1.1–3.7 and 2.4: CI 1.6–3.6), and having a post-operative complication (HR 2.2:CI 1.5–3.2). Pre-surgical STT was not a significant predictor of death on univariate or multivariate analysis (p 0.88 and p 0.20). CONCLUSIONS: There was no significant difference in overall survival in patients receiving presurgical STT followed by CRN compared to patients treated with immediate CRN. Larger prospective studies are necessary to answer the question of the need for and the most appropriate timing of cytoreductive nephrectomy in patients with metastatic RCC.
Published Version
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