1717 BILHARZIAL RELATED BLADDER CANCER: PATHOLOGICAL CHARACTERISTICS AND VALUE OF CYCLOOXYGENASE-2 EXPRESSION

Abstract

You have accessJournal of UrologyBladder Cancer: Invasive/Metastatic Disease II1 Apr 20101717 BILHARZIAL RELATED BLADDER CANCER: PATHOLOGICAL CHARACTERISTICS AND VALUE OF CYCLOOXYGENASE-2 EXPRESSION Ramy Youssef, Payal Kapur, Wareef Kabbani, Shahrokh Shariat, Ahmed Mosbah, Hassan Abol-Enein, Mohamed Ghoniem, and Yair Lotan Ramy YoussefRamy Youssef Dallas, TX More articles by this author , Payal KapurPayal Kapur Dallas, TX More articles by this author , Wareef KabbaniWareef Kabbani Dallas, TX More articles by this author , Shahrokh ShariatShahrokh Shariat Dallas, TX More articles by this author , Ahmed MosbahAhmed Mosbah Mansoura, Egypt More articles by this author , Hassan Abol-EneinHassan Abol-Enein Mansoura, Egypt More articles by this author , Mohamed GhoniemMohamed Ghoniem Mansoura, Egypt More articles by this author , and Yair LotanYair Lotan Dallas, TX More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1564AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We assessed the expression pattern of cyclooxygenase-2 (cox-2) in bilharzial and non-bilharzial related bladder cancer (BBC and NBBC) and its association with poor clinical outcome after radical cystectomy (RC). We also determined the clinico-pathological differences between BBC and NBBC. METHODS Immunohistochemical(IHC) staining for cox-2 was performed on archival bladder specimens from 315 patients treated with RC between 1997-2003. Patients were divided into 2 groups: Group 1 comprised 205 patients (65%) with BBC and group 2 comprised 110 patients (35%) with NBBC. Clinico-pathological differences were compared. Altered IHC expression of cox-2 was correlated with clinical outcome in both groups. Mean follow-up was 3 y (range 0-8). RESULTS The study included 315 patients [239 (76%) males and 76 (24%) females] with mean age 53.5 y (range 31-79). Pathological diagnosis showed PT1, PT2, PT3 and PT4 in 12%, 40%, 40% and 8% of patients respectively. There was no significant difference in pathological T stage, LN, lymphovascular invasion, and clinical outcome between both study groups. However, there was significant difference in pathological cell type, grade, tumor architecture between both groups [p = 0.00] as well as cox-2 alterations (p=0.045). In group 1: 2/3 of patients showed non-urothelial carcinoma, 85% were low grade and 2/3 had non-papillary architecture. In group 2: 2/3 showed urothelial carcinoma, 85% showed high grade and 2/3 had papillary architecture. Recurrence was associated with altered cox-2 expression in group 1 but not in group 2 (p = 0.012 and 0.38 respectively). CONCLUSIONS BBC differs pathologically and biologically from NBBC. BBCs are more frequently low-grade, non- papillary and non-urothelial cancers. BBCs with cox-2 alterations are associated with worse outcome after RC. Our findings support the need for further evaluation of cox-2 and inflammatory signaling pathways as well as cox-2-targeted prevention or therapies in BBC. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e663 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ramy Youssef Dallas, TX More articles by this author Payal Kapur Dallas, TX More articles by this author Wareef Kabbani Dallas, TX More articles by this author Shahrokh Shariat Dallas, TX More articles by this author Ahmed Mosbah Mansoura, Egypt More articles by this author Hassan Abol-Enein Mansoura, Egypt More articles by this author Mohamed Ghoniem Mansoura, Egypt More articles by this author Yair Lotan Dallas, TX More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...