牙周病與風濕性關節炎之相關性－白細胞介素－17重要性之探討

Abstract

The significant association between periodontal disease and rheumatoid arthritis has already been established. Similarities between these 2 diseases can be discussed in terms of the physiological structure, epidemiology, pathogenicity, clinical features, and genetic properties. Multiple factors are involved in both diseases; however, little is known about the relationship between periodontal disease and rheumatoid arthritis. The purpose of this review was to investigate the role of interleukin (IL)-17 in order to better understand the relationship between periodontal disease and rheumatoid arthritis. According to recent findings, IL-17 is exclusively secreted by T helper cells (Th)-17. Th17 cells are a newly found T-cell subset that coordinate innate immunity and adapted immunity. In addition, IL-17 secreted by Th17 cells interferes with interactions among autoimmune and infectious inflammatory responses. Moreover, IL-17 can directly or indirectly increase the expression of matrix metalloproteinase (MMP) and promote osteoclastogenesis. Therefore, IL-17 plays a crucial role in both diseases. In addition, while T cells are abundant in both lesions, classic T cell-derived cytokines are scarce except for IL-17. This suggests that both diseases are strongly associated with IL-17. IL-17 was found to have higher expression in the early stage of periodontal disease, and IL-17 may greatly contribute to the initiation of destructive progression. In this review, we reestablished and strengthened the relationship between periodontal disease and rheumatoid arthritis through understanding the role and expression of IL-17. We highlight the field for discussion to inspire novel clinical treatments for periodontal disease, rheumatoid arthritis, and other chronic inflammatory diseases.