16P - Next-Generation Sequencing of Epigenetically Silenced Genes in Brcax Cases and Ancestry Matched Controls

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Breast cancer is the leading cause of cancer deaths in females worldwide occurring in both hereditary and sporadic forms. However, only about 20% of familial breast cancer cases are attributed to mutations in BRCA1 and BRCA2, while a further 5–10% is attributed to mutations in other rare susceptibility genes such as TP53, ATM and CHEK2 (1). Despite extensive efforts to explain the missing heritability of this disease, the majority of familial clustering in breast cancer remains largely unexplained.