Abstract

The gut counts trillions of microorganisms, while the skin is covered with billions of microbes, mostly bacteria, but also fungal, archaeal, and viral species that inhabit the skin and its appendages. The microbiome is a key regulator for the immune system and aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. A barrier disruption in combination with an imbalance in the skin and/ or gut microbiome is correlated with an altered immune response, which promotes the development of several skin diseases including psoriasis, dandruff and seborrheic dermatitis, atopic dermatitis, rosacea, acne vulgaris, and even skin cancer.

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