Abstract

The myocardium responds to injury by several cellular and molecular strategies. This chapter highlights the promise of combining stem cell and gene therapy approaches to enhance endogenous cardiac repair. The goal of stem cell therapy is to reverse the progression of cardiac disease, restore heart performance and promote endogenous repair by enhancing the viability and endurance of cardiac stem cells within the injured myocardium. Gene therapy has the potential to improve homing and integration of these cells within the injured myocardium. Combining gene and cell therapy can have a significant impact on repairing the injured myocardium.

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