16 - Applications of alignment-free sequence descriptors in the characterization of sequences in the age of big data: a case study with Zika virus, SARS, MERS, and COVID-19

Abstract

This chapter gives a detailed presentation of the theoretical background and computational approaches to the utility of alignment-free sequence descriptors and multidimensional variable reduction methods in the characterization and visualization of biological sequence data. The utility of such novel methods developed by the authors of this chapter is shown using data on case studies of severe acute respiratory syndrome, Middle East respiratory syndrome, Coronavirus disease-2019, and Zika viruses.