159P Peripheral T-lymphocytes senescence and response to neoadjuvant therapy (NAT) in operable breast cancer (BC)

Abstract

Increasing evidence suggests a link between T-cell senescence and tumor prognosis. In particular, high levels of circulating senescent T-lymphocytes have been correlated with a worse response to treatment. In this perspective, a therapeutic approach aimed at T-cell senescence clearance is regarded as an innovative strategy and is currently under investigation in pre-clinical and clinical models. The purpose of the present study is to characterize the impact of T-cell senescence as a predictive factor of response in patients with operable BC treated with NAT, according to the different biological subtypes.