15886 In silico analysis of gamma-secretase complex mutations in hidradenitis suppurativa demonstrates disease-specific substrate recognition and cleavage alterations

Abstract

Familial hidradenitis suppurativa and familial Alzheimer disease are both associated with gamma-secretase complex mutations; however, the 2 diseases are not epidemiologically associated. Understanding the molecular differences between the 2 diseases may aid in development of hypotheses for differing pathogenesis and ultimately, targets for detection.