1552P - Characteristics of the psychosomatic state of patients with lung cancer

Abstract

Background: The important issue of psychophysiological adaptation to malignant process is poorly studied. The aim of the research was to elucidate characteristics of the psychic, adaptive and hormonal status of patients with lung cancer (LC). Methods: Studies were performed in 28 LC patients with receiving surgery and chemoradiotherapy. The patients were divided into 3 groups: 1 - unresectable tumors, 2 - resectable tumors with metastases, 3 - resectable tumors without detected metastases. Personal (PA) and situational anxiety (SA) (Spielberger-Khanin test), depression (Zung test), the types of the mental response to disease (LOBI, Bechterew Institute Personality Inventory) were evaluated. With the help of blood count and the original computer program "Antistress", we calculated the quantitative indicator (QI) of the general nonspecific adaptation reactions of the body (AR) (Garkavi L. H. et al., 1975). Hormone levels of thyroid and pituitary-adrenal (PAS) systems in the blood were determined by electrochemiluminescent method (Cobase 411E). Results: The studied groups did not differ in PA and SA. The signs of tension of the PAS, elevated thyroxine level and decline in the adaptive status were noted. At the same time, QI of AR in patients of the group 3 was 1.8-2.7 times higher than in patients of other groups (p < 0.05). Depression was observed in only one patient. The euphoric type of response to the disease dominated in the groups (39% of cases), the harmonic type was the second most frequent (18% of cases). The patients of group 3 with euphoric reaction (referred to non-rational types of response) were characterized by an uncomplicated postoperative period and the maximal QI of AR in the studied groups, which exceeded by 2 times the indices in the patients of group 3 with harmonic and other reactions (p < 0.01). Conclusions: QI of AR of patients with LC reflected the prevalence of the malignant process. In these patients depression was not expressed, and the euphoric reaction dominated. That could be due to central effects of thyroxin. We assumed that the euphoric reaction in the patients with resectable LC without detected metastases was a favorable diagnostic characteristic. So the questions arise about the clarification of the concept of the euphoric reaction and the ways of its identification. Legal entity responsible for the study: Ministry of Health of the Russian Federation. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.