Abstract
High plasma threonine concentration reported in preterm infants fed whey-predominant and whey-hydrolysate formulas may be related to the high threonine content of the glycomácropeptide fraction of κ-casein present in the soluble fraction of bovine milk protein. The aim of the present study was to evaluate the interest of a whey-predominant formula free of κ-casein on the plasma and urinary threonine concentrations in preterm infants. Fourtheen healthy preterm infants appropriate for gestational age (BW: 1430±347g; GA: 31±2 wks) were enrolled to receive in a crossover study a conventional (THR⊕ = 5.89%) and an experimental (THR⊖ = 4.94%) formula for one week each. Pre- and post-prandial plasma AA concentrations and urinary AA excretion were determined at the end of each feeding regimen (in mean ± 28 d and ± 35 d of life). Results shows a significantly lower plasma threonine concentration in preterm infants fed THR⊕ formula. In addition a significant reduction in plasma and urinary threonine concentrations were observed in the infants receiving succesively the THR⊕ and THR⊖ formulas. By contrast from THR⊖ to THR⊕, post-prandial plasma threonine increases significantly but the difference in pre-prandial plasma and in urinary AA concentrations were not significantly different. Table In conclusion, our study suggests that the incidence of hyperthreoninemia may be reduced in preterm infants fed a whey predominant formula without glycomacropeptide fraction of κ-casein.
Published Version
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