Abstract
Background: The interplay between the tumor cells and regulatory microenvironment proteins such as chitinase-like proteins YKL-39, YKL-40, SI-CLP and stabilin-1 may play a critical role in the disease progression and response to treatment. The aim of this study was to examine the expression levels of the CHI3L2, CHI3L1, CHID1, STAB1 gene coding chitinase-like proteins in relation to tamoxifen treatment in hormone-receptor positive breast cancer patients; and the relationship between these levels and expression of Akt1-associated genes.
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