1509 Characterizing somatostatin receptor 2 (SSTR2) expression and the immune landscape of olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC), and sinonasal undifferentiated carcinoma (SNUC)

Dara Bracken-Clarke,Harris Krause,Nishant Gandhi,Alex Farrell,Heloisa Soares,Minh Phan,Rusha Patel,Ari Vanderwalde,Nyall London,James L Gulley,Emil Lou,Charalampos S Floudas

doi:10.1136/jitc-2023-sitc2023.1509

1509 Characterizing somatostatin receptor 2 (SSTR2) expression and the immune landscape of olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC), and sinonasal undifferentiated carcinoma (SNUC)

Dara Bracken-Clarke, Harris Krause + Show 10 more

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https://doi.org/10.1136/jitc-2023-sitc2023.1509

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Journal: Journal for ImmunoTherapy of Cancer	Publication Date: Nov 1, 2023
License type: CC BY-NC 4.0

Affiliation: Caris Life Sciences (United States), Huntsman Cancer Institute, University of Oklahoma Health Sciences Center

#Sinonasal Undifferentiated Carcinoma #Sinonasal Neuroendocrine Carcinoma #Olfactory Neuroblastoma #Expression Of Somatostatin Receptor 2 #Somatostatin Receptor 2 #Caris Life Sciences #Immune Cell Fractions #Cell-inflamed Tumors #EBER ISH #Sinonasal Carcinoma

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BackgroundONB, SNEC and SNUC are rare sinonasal neoplasms demonstrating varying neuroendocrine characteristics, with limited systemic treatment options. ONB expresses SSTR2, diagnostically and therapeutically actionable; SNUC is heterogeneous and a diagnosis...

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1509 Characterizing somatostatin receptor 2 (SSTR2) expression and the immune landscape of olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC), and sinonasal undifferentiated carcinoma (SNUC)